产品说明
一般描述
P-Rex1 protein is a Rac-GEF, guanine nucleotide exchange factor, for the RHO family of GTPases, connecting Gβγ and phosphatidylinositol 3-kinase signaling to Rac activation. P-Rex1 promotes membrane ruffling and links mTOR signaling to Rac activation of cell migration.
Rabbit polyclonal PREX1 antibody reacts with human phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein.
免疫原
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein recombinant protein epitope signature tag (PrEST)
应用
Rabbit polyclonal PREX1 antibody is used to tag phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Ptdlns) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Ptdlns) in cell mobilization at the level of Rac activation.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST86391.
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| 人类蛋白质图谱编号 | HPA001927 Human Protein Atlas characterization data |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 产品线 | Prestige Antibodies® Powered by Atlas Antibodies |
| 形式 | buffered aqueous glycerol solution |
| species reactivity | human |
| 包装 | antibody small pack of 25 μL |
| 增强验证 | orthogonal RNAseq Learn more about Antibody Enhanced Validation |
| technique(s) | immunofluorescence: 0.25-2 μg/mL immunohistochemistry: 1:200-1:500 |
| 免疫原序列 | CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEP |
| UniProt登记号 | Q8TCU6 |
| application(s) | research pathology |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PREX1(57580) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
