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Anti-phospho-SP1 (pThr739) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300670
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Specific protein 1 (Sp1) is a transcription regulator that has a transactivation domain at the N-terminus and a DNA-binding domain at the C-terminus, that contain three zinc fingers (ZF). It belongs to transcription factor family and is located on chromosome 12q13.

免疫原

Peptide sequence around phosphorylation site of threonine 739 (T-A-Tp-P-S), according to the protein NP_612482.2

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Anti-phospho-SP1 (pThr739) antibody has been used in immunohistochemistry.

生化/生理作用

Specific protein 1 (Sp1) controls the up- and down-regulation of hCtr1 (human high-affinity copper transporter 1). It controls the expression of several genes that participates in differentiation, cell cycle and oncogenesis. It has the ability to bind GC/GT‐ ich promoter elements with the help of C(2)H(2)‐ ype zinc fingers at the C‐ erminal domain.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~90 kDa
species reactivityhuman, rat, mouse
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(T-A-Tp-P-S)
NCBI登记号NM_138473.2
UniProt登记号P08047
运输wet ice
储存温度−20℃
Gene Informationhuman ... SP1(6667)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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