产品说明
一般描述
Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.
免疫原
The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.
Immunogen Range: 716-765
生化/生理作用
Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 110 kDa |
| species reactivity | rat, mouse, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | Q06418 Q12866 |
| UniProt登记号 | Q06418 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MERTK(10461), TYRO3(7301) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
