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Anti-phospho-FGFR4 (pTyr642) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4301393
规格纯度
affinity isolated antibody
参考价格
6141.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Fibroblast growth factor receptor 4 (FGFR4) protein is a tyrosine kinase (TK) receptor comprising an extracellular domain, a transmembrane domain, and an intracellular domain. FGFR4 is expressed in the adrenal cortex, bile duct, cervix, cornea, heart, hepatocyte, intestine, kidney, liver, lung, lymph node, mammary gland, muscle, ovary, pituitary gland, renal tubular epithelium, retina, skin, spleen, stomach, ureter, urothelium, and uterus. FGFR4 gene is located on human chromosome 5q35.2.

特异性

The antibody detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.

免疫原

Peptide sequence around phosphorylation site of tyrosine 642(I-D-Y(p)-Y-K) derived from Human FGFR4 .

生化/生理作用

Fibroblast growth factor receptor 4 (FGFR4) protein possesses tyrosine-protein kinase activity and serves as a cell-surface receptor for fibroblast growth factors. It regulates cell proliferation, differentiation, and migration. FGFR4 also participates in survival during embryonic development. It helps with tissue homeostasis, tissue repair, angiogenesis, and inflammation in adults. FGFR4 is expressed at a high level in various cancer types. It plays a key role in tumor subtype differentiation in luminal breast cancer and metastatic disease. Oncogenic mutations of the FGFR4 gene are associated with rhabdomyosarcoma (RMS) and primary gastric cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 90 kDa
species reactivityhuman
浓度1.0 mg/mL
technique(s)western blot: 1:500-1:1000 (Cell Lysate)
同位素/亚型IgG
登记号NP_002002.3.
UniProt登记号P22455
运输wet ice
储存温度−20℃
Gene Informationhuman ... FGFR4(2264)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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