产品说明
一般描述
NLRP12 (NACHT, LRR and PYD domains-containing protein 12) is also known as Monarch-1 or PYRIN-containing APAF1-like protein 7 (PYPAF7). NLRP12 is thought to mediate activation of CASP1 (via ASC) and NF-kappa-B (via IKK). NLRP12 has been detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes, and is regulated by nitric oxide. NLRP12 defects can cause familial cold autoinflammatory syndrome type 2 (FCAS2).
特异性
Other homologies: Mouse (91% sequence homology).
免疫原
KLH-conjugated linear peptide corresponding to human NLRP12.
应用
Flow Cytometry Analysis: 0.5 µg from a representative lot detected NLRP12 in rat basophil leukemia (RBL).
Anti-NLRP12 Antibody is a highly specific rabbit polyclonal antibody, that targets NLRP & has been tested in western blotting & Flow Cytometry.
Research Category
Signaling
Research Sub Category
Immunological Signaling
质量
Evaluated by Western Blotting in rat basophil leukemia (RBL) cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected NLRP12 in 10 µg of rat basophil leukemia (RBL) cell lysate.
目标描述
~110 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing this antibody recognizes isoforms 1 through 4 at ~120 kDa, ~114 kDa, ~107 kDa, and ~102 kDa
外形
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Rat basophil leukemia (RBL) cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 纯化方式 | affinity chromatography |
| species reactivity | rat |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), human (immunogen homology) |
| technique(s) | flow cytometry: suitable western blot: suitable |
| NCBI登记号 | NP_150639 |
| UniProt登记号 | P59046 |
| 运输 | wet ice |
| Gene Information | human ... NLRP12(91662) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
