Anti-IRGM Antibody

产品说明

一般描述

Immunity-related GTPase family M protein (IRGM), also known as Interferon-inducible protein 1 (IFI1) and LPS-stimulated RAW 264.7 macrophage protein 47 homolog (LRG-47), is a member of the interferon-inducible GTPase family. It induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. IRGM is expressed in colon, small bowel, and peripheral blood leukocytes. Mutations in IRGM have been assoicated with inflammatory bowel disease type 19 which is subdivided into Crohn′s disease and ulcerative colitis phenotypes.

特异性

This antibody recognizes the intermediate domain of IRGM.

免疫原

KLH-conjugated linear peptide corresponding to the intermediate domain of human IRGM.

应用

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected IRGM in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IRGM in human brain cells.
Detect Immunity-related GTPase family M protein using this rabbit polyclonal antibody, Anti-IRGM Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.

质量

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected IRGM in 15 µg of human brain tissue lysate.

目标描述

~31 kDa observed. Uncharacterized bands may appear in some lysates.

外形

Antigen Affinity Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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