Anti-Frataxin Antibody

产品说明

一般描述

Frataxin is a nuclear encoded protein that is found in the mitochondria. This protein is not well understood but may be involved with iron sulfur clusters. In humans the gene is localized on chromosome 9 and is highly conserved during evolution. The gene is expressed in every cell, although in varying levels in different tissues and during development. The specific function of Frataxin is still unknown, but it has been shown to play a role in iron metabolism. Studies have demonstrated that the deletion of the Frataxin gene in yeast results in iron accumulation in mitochondria and loss of respiration. Recombinant human Frataxin has been shown to bind iron in vitro, and increased mitochondrial iron levels have been observed in patients with Friedreich′s Ataxia (FRDA).

特异性

Cat. # AB15080 recognizes Frataxin.

免疫原

GST-tagged Frataxin corresponding to mature chain.
Epitope: mature chain

应用

This Anti-Frataxin Antibody is validated for use in WB for the detection of Frataxin.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

质量

Routinely evaluated by Western Blot on Human heart lysates.

Western Blot Analysis: 1:1,000 - 1:10,000 dilution of this lot detected Frataxin on 10 ug of human heart lysate

目标描述

Approx. 18 kDa

外形

Rabbit polyclonal serum in buffer containing 0.05% NaN3.
Format: Purified
GST-depleted sera

储存及稳定性

Stable for 1 year at -20ºC from date of receipt.

分析说明

Control
Human heart lysate.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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