Rabbit anti-p53 Antibody, Affinity Purified

产品说明

一般描述

p53, also known as transformation related protein 53 (TRP53), is encoded by the gene mapped to human chromosome 17p13.1. p53 is a tumor suppressor gene expressed in a wide variety of tissues. The gene codes for a tetrameric nuclear DNA-binding phosphoprotein.

免疫原

The epitope recognized by PLA0072 maps to a region between residues 50 and 100 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).

生化/生理作用

Tumor suppressor p53 has an ability to induce cell cycle arrest. It also plays a key role in DNA repair, senescence and apoptosis. It binds to simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. Mutation in the p53 gene is associated with the development of various types of cancers, such as breast, ovarian, bladder, colon and lung cancer.

外形

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

其他说明

p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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