Anti-mGluR4 Antibody

产品说明

一般描述

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

特异性

Reactivity with other species has not been determined.
Cat. # AB15097 recognizes mGluR4 (GRM4).

免疫原

Recombinant Protein.

应用

This Anti-mGluR4 Antibody is validated for use in WB for the detection of mGluR4.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

质量

Western Blot:
Mouse Brain Lysate.

目标描述

~101 kDa

外形

Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Format: Purified
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8ºC from date of receipt.

分析说明

Control
Mouse Brain Lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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