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Anti-PTGDS Antibody

品牌
Sigma-Aldrich
货号
ABN253
包装型号
规格纯度
from rabbit
参考价格
6022.61 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Prostaglandin-H2 D-isomerase (PTGDS), also known the Lipocalin-type prostaglandin-D synthase, catalyzes the conversion of PGH2 to PGD2. PTGDS serves both as a PGD2-synthesizing enzyme and as an extracellular transporter of various lipophilic small molecules. It is the only enzyme in the lipocalin type protein family, members of which mainly act as binding proteins. It has been shown to bind various small, lipophilic compounds such as retinoic acid, biliverdin, bilirubin, retinoic acid, and thyroid hormone and may act as a scavenger for harmful hydrophobic molecules. In cells it is localized in the endoplasm reticulum, golgi apparatus, cell membrane, and is also secreted. PTGDS is involved in several central nervous system functions, such as sedation, pain regulation and non-rapid eye movement sleep. It is suggested to be involved in development and maintenance of the blood-brain, blood-retina, and blood-aqueous humor barriers and may also play a role in maturation and maintenance of the central nervous system.

特异性

Other homologies: Feline (92% sequence homology), Canine (83% sequence homology), Mouse (75% sequence homology), no homology to Rat detected.

免疫原

KLH-conjugated linear peptide corresponding to human PTGDS.

应用

Detect the PTGDS protein using this Anti-PTGDS validated for use in WB & IHC.
Research Category
Neuroscience
Immunohistochemistry Analysis: 1:100 dilution from a representative lot detected PTGDS in human pons/midbrain and human cardiac myocytes.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blot in human testis tissue lysate.

Western Blot Analysis: 0.2 µg/mL of this antibody detected PTGDS in 10 µg of human testis tissue lysate.

目标描述

~30 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein A purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human testis tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified antibody
antibody product typeprimary antibodies
克隆polyclonal
species reactivityhuman
species reactivity (predicted by homology)rhesus macaque (based on 100% sequence homology)
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_000945
UniProt登记号P41222
运输wet ice
Gene Informationhuman ... PTGDS(5730)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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