产品说明
一般描述
LDL receptor-related protein 1B (LRP1B) belongs to the low-density lipoprotein (LDL) receptor gene family, including LDLR, LRPs (low density lipoprotein related proteins), megalin/GP330, VLDLR (very low density lipoprotein receptor) and ApoER2.
免疫原
synthetic peptide corresponding to a sequence near the C-terminus of human LRP1B, conjugated to KLH. The corresponding sequence is identical in mouse LRP1B.
应用
Anti-LRP1B (C-terminal region) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
LDL receptor-related protein 1B (LRP1B) is a candidate tumor suppressor gene, that is inactivated in several types of human malignancies, including non-small cell lung cancer (NSCLC) and plays an important role in tumorigenesis. It regulates the endocytic trafficking of the β-amyloid precursor protein (APP) and reduces the production of amyloid-β peptide (Ab) involved in the pathogenesis of Alzheimer′s disease. LRP1B regulates the degradation of the platelet derived growth factor-β receptor (PDGFR-β) and is implicated in the development of atherosclerosis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~190 kDa (Rat) antigen ~200 kDa (Human) |
| species reactivity | human, mouse, rat |
| 浓度 | ~1.5 mg/mL |
| technique(s) | immunoprecipitation (IP): 5-10 μg using extracts of HEK-293T cells overexpressing human LRP1B. indirect immunofluorescence: 1-2 μg/mL using HEK-293T cells overexpressing human LRP1B. western blot: 1.5-3.0 μg/mL using extracts of rat brain (S1 fraction) and mouse brain (S1 fraction). |
| UniProt登记号 | Q9NZR2 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... LRP1B(53353) mouse ... Lrp1b(94217) rat ... Lrp1b(311926) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
