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Anti-Vitamin D Receptor antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4503071
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Anti-Vitamin D Receptor Antibody detects endogenous levels of total Vitamin D Receptor protein.
Vitamin D receptor (VDR) gene codes for a nuclear receptor. It is expressed at a high level in the hypothalamus and the large neurons of the substantia nigra in the brain. VDR gene comprises 14 exons and 6 untranslated exons with alternative splicing sites. It is mapped to human chromosome 12q13.1.

免疫原

The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor.

Immunogen Range: 181-230

应用

Anti-Vitamin D Receptor antibody produced in rabbit has been used in western blotting and immunofluorescence staining (1:200) (1:100).

生化/生理作用

Vitamin D receptor (VDR) protein modulates genes associated with inflammation, chronic diseases, oxidative damage, and the metabolism of bone. VDR gene is involved in the susceptibility of type 2 diabetes mellitus (T2DM). The nuclear receptor encoded by the VDR gene possesses pluripotent effects. It is capable of specifically binding the elements of DNA response when bound to the ligand. VDR acts as a receptor for 1,25 dihydroxyvitamin D3 (1,25(OH)2 D3). It facilitates the biological activities of vitamin D. Inadequacy of vitamin D is a risk factor for Alzheimer′s disease (AD).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00802899
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 48 kDa
species reactivityhuman
浓度~1 mg/mL
technique(s)ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号P11473
UniProt登记号P11473
运输wet ice
储存温度−20℃
Gene Informationhuman ... VDR(7421)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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