位置:首页 > 品牌 > Sigma-Aldrich >

Anti-Ezrin antibody produced in rabbit

品牌
Sigma-Aldrich
货号
E1281
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
6923.34 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Ezrin is a 80kDa membrane-associated protein that belongs to ERM (Ezrin/Radixin/Moesin) family. Ezrin is found predominantly in polarized epithelial cells such as intestinal epithelial cells, gastric parietal cells, epithelial cells of the kidney proximal tubule, terminal bronchiole of the lung, and in mesothelia.

免疫原

synthetic peptide corresponding to amino acids 479-498 of human ezrin with N-terminal added cysteine, conjugated to KLH. The corresponding sequence in rat and mouse differs by three amino acids.

应用

Anti-Ezrin antibody produced in rabbit has been used in:

  • immunolocalization studies
  • immunostaining
  • immunofluorescence and immunohistochemistry
  • immunoblot

生化/生理作用

Cultured neuronal cells do express ezrin to some extent, and whole brain tissue expresses low levels of ezrin. Ezrin expression is associated with malignancy in astrocytoma, osteosarcoma, mammary and pancreatic adenocarcinomas, and in cutaneous and uveal melanomas.
Ezrin promotes cell adhesion. The NH2-terminal domain negatively regulates membrane spreading and elongation properties of ezrin COOH-terminal domain. The members of ERM family are usually involved in cross-linking of plasma membrane and actin filaments. ERM proteins are involved in cell adhesion, cell shape determination, migration, and the organization of cell surface structures. They are also involved in signal transduction and apoptosis. Ezrin has been implicated in tumor progression and metastatic spread.

外形

Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00211933
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~80 kDa
species reactivityhuman, rat
technique(s)immunohistochemistry: 20-40 μg/mL
immunoprecipitation (IP): 0.5-1 μg using RIPA extract of human A431 cells
indirect immunofluorescence: 10-20 μg/mL
western blot (chemiluminescent): 0.5-1 μg/mL using whole extract of rat NRK cells
UniProt登记号P15311
运输dry ice
储存温度−20℃
Gene Informationhuman ... EZR(7430)
mouse ... Ezr(22350)
rat ... Ezr(54319)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号