产品说明
一般描述
Riboflavin 5′-monophosphate is a derivative of riboflavin, a water-soluble vitamin.
应用
核黄素5′-单磷酸可用作底物，研究FMN磷酸水解酶的特异性和动力学特性。 FMN也可用于通过核糖开关研究基于分子感应的基因调控。
Riboflavin 5′-monophosphate sodium salt hydrate has been used in the preparation of hypo-osmolar riboflavin formulation:
- to evaluate the riboflavin (RF) concentration and distribution in the corneal stroma
- to study corneal resistance to enzymatic digestion
- as a photosensitizer to evaluate the efficacy and safety of photochemical corneal stiffening using ex vivo and in vivo rabbit eye models
包装
5, 25, 100 g in glass bottle
生化/生理作用
Riboflavin 5′-monophosphate (FMN) serves as a cofactor for flavoenzymes. It is used as a prosthetic group by oxidoreductase (one and two-electron transfer) enzymes, also called flavoproteins, such as nicotinamide adenine dinucleotide (NADH) dehydrogenases, nitric oxide synthases, nitric oxide reductase, and nitrilotriacetate monooxygenases. These enzymes protect cells from oxidative stress and apoptosis. Any alteration in the levels of FMN caused due to abnormal riboflavin metabolism leads to mitochondrial dysfunction and diminished energy levels. This results in disorders related to riboflavin such as cataracts, neurodegenerative and cardiovascular diseases. FMN is associated with metabolic pathways of amino acids, fatty acids, and purines. It is involved in cellular growth and development mediated by the oxidation-reduction reaction.
质量
游离核黄素：≤6.0%
核黄素二磷酸：≤6.0%(以核黄素计)
基本信息
| 经验(实验)分子式 | C17H20N4NaO9P · xH2O |
| 分子量 | 478.33 (anhydrous basis) |
| Beilstein | 4106529 |
| MDL编号 | MFCD00150992 |
| eCl@ss | 34058005 |
| PubChem化学物质编号 | 24894910 |
| NACRES | NA.51 |
产品性质
| 质量水平 | 200 |
| 测定 | 73-79% (fluorimetric) |
| 形式 | powder |
| 溶解性 | water: 50 mg/mL, clear, orange |
| 储存温度 | −20℃ |
| SMILES string | O.[Na+].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O)c2cc1C |
| InChI | 1S/C17H21N4O9P.Na.H2O/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29;;/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29);;1H2/q;+1;/p-1/t11-,12+,14-;;/m0../s1 |
| InChI key | BHRVCJBIICJWTH-APQIITSESA-M |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
