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Deracoxib

品牌
Sigma-Aldrich
CAS
169590-41-4
货号
SML2014
规格纯度
≥98% (HPLC)
参考价格
1387.85 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Deracoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with >48-fold selectivity over COX-1 (IC50 of 203-189 nM against COX-2-dependent PGE2 production vs. IC50 of 9.85-9.96 μM against COX-1-dependent TxB2 production in dog whole blood). Deracoxib is also reported to exhibit inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3) as well as positive modulatory effiacy toward 2-APB-stimulated transient receptor potential vanilloid 3 channel (TRPV3) activity.

基本信息

经验(实验)分子式C17H14F3N3O3S
分子量397.37
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to brown
溶解性DMSO: 2 mg/mL, clear
储存温度room temp
InChI1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
InChI keyWAZQAZKAZLXFMK-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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