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Apigenin

芹菜素

品牌
Sigma-Aldrich
CAS
520-36-5
货号
SMB00702
规格纯度
≥97% (TLC), from citrus
参考价格
559.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley.

包装

5 mg in glass bottle
25, 100 mg in poly bottle

生化/生理作用

Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects.
一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
EC 号208-292-3
MDL编号MFCD00006831
NACRESNA.79

产品性质

质量水平200
测定≥97% (TLC)
形式powder
mp>300 ℃ (lit.)
溶解性DMSO: 27 mg/mL
1 M KOH: 50 mg/mL
储存温度−20℃
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N
Gene Informationhuman ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

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