产品介绍：
产品说明
应用
(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABAB receptor agonist:
- as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
- to test its effects on in vivo motor function tests and performance of mutant mice
- to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
- to test its effect in reducing dendritic excitability in Purkinje neurons
生化/生理作用
Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABA B 受体激动剂；骨骼肌松弛剂；解痉剂。
基本信息
| 经验(实验)分子式 | C10H12ClNO2 |
| 分子量 | 213.66 |
| EC 号 | 214-486-9 |
| MDL编号 | MFCD00055143 |
| PubChem化学物质编号 | 24278146 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | solid |
| 颜色 | white to very faintly yellow |
| 溶解性 | 1 M HCl: 50 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | ClC1=CC=C(C(CN)CC(O)=O)C=C1 |
| InChI | 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) |
| InChI key | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| Gene Information | human ... GABBR1(2550), GABBR2(9568) rat ... Gabbr1(81657), Gabra2(29706) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
