产品介绍：
产品说明
一般描述
Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.
应用
cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:
- to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
- to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
- to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice
生化/生理作用
Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.
5-脂氧合酶抑制剂；可减少血栓素 A2 的生成。
基本信息
| 线性分子式 | CH3(CH2CH=CH)5(CH2)3CO2Na |
| 分子量 | 324.43 |
| MDL编号 | MFCD00079184 |
| PubChem化学物质编号 | 24894631 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥99% (capillary GC) |
| 形式 | film or powder |
| 颜色 | white to off-white |
| 溶解性 | methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | [Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O |
| InChI | 1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;; |
| InChI key | TVEGTERCKGGVCJ-LIJGWLRISA-N |
| Gene Information | human ... ALOX5(240) mouse ... ALOX5(11689) rat ... ALOX5(25290) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
