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6,8-Bis(benzylthio)-octanoic acid

品牌
Sigma-Aldrich
CAS
95809-78-2
货号
SML0404
规格纯度
≥98% (HPLC)
参考价格
1254.85 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:

  • to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cells
  • to induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysates
  • to validate basal respiration in tissue respirometry

包装

5, 25 mg in glass bottle

生化/生理作用

6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.
6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer.

其他说明

Air Sensitive

基本信息

经验(实验)分子式C22H28O2S2
分子量388.59
MDL编号MFCD22420826
PubChem化学物质编号329825400
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 15 mg/mL (clear solution)
储存温度2-8℃
SMILES stringOC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2
InChI1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)
InChI keyZYRLHJIMTROTBO-UHFFFAOYSA-N

安全信息

象形图GHS09
警示用语:Warning
危险声明H410
预防措施声明P273 - P501
危险分类Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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