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SL327

品牌
Sigma-Aldrich
CAS
305350-87-2
货号
S4069
规格纯度
≥98% (HPLC), Mixture of E & Z isomers, solid
参考价格
2038.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

包装

5, 25 mg in glass bottle

生化/生理作用

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

基本信息

经验(实验)分子式C16H12F3N3S
分子量335.35
MDL编号MFCD06411432
PubChem化学物质编号329824537
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
储存条件desiccated
protect from light
颜色 white to off-white
mp127-128.2 ℃
溶解性DMSO: >10 mg/mL
H2O: insoluble
储存温度2-8℃
SMILES stringN\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
InChI1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChI keyJLOXTZFYJNCPIS-FYWRMAATSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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