产品介绍：
产品说明
应用
Pomalidomide has been used:
- to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
- for apoptosis studies and intracellular calcium analysis
- as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells
包装
5, 25 mg in glass bottle
生化/生理作用
Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key γ-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).
泊马度胺是第二代免疫调节剂，TNF-α抑制剂和沙利度胺类似物。
特点和优势
该化合物出现在《受体分类和信号转导手册》 细胞因子受体(肿瘤坏死受体家族) 页面。要浏览其他手册页， 单击此处 。
基本信息
| 经验(实验)分子式 | C13H11N3O4 |
| 分子量 | 273.24 |
| MDL编号 | MFCD12756407 |
| PubChem化学物质编号 | 329819974 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | yellow |
| 溶解性 | DMSO: ≥14 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 |
| InChI | 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) |
| InChI key | UVSMNLNDYGZFPF-UHFFFAOYSA-N |
| Gene Information | human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H360D |
| 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| 危险分类 | Repr. 1B |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
