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UCH-L1 Inhibitor-CAS 668467-91-2-Calbiochem

品牌
Sigma-Aldrich
CAS
668467-91-2
货号
662086
规格纯度
The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
参考价格
2165.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent, reversible, competitive, and active site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) (Ki = 400 nM; IC50 = 880 nM). Exhibits ~28-fold greater selectivity for UCH-L1 compared to UCH-L3 (Cat. No. 662090). Shown to increase proliferation of the UCH-L1-expressing tumor cell line, SH-SY5Y, at a concentration of 5 µM. Useful tool for studying the roles of UCH-L1 in cancer, Parkinson′s disease, and other neurological disorders. Cell-permeability is reported to vary from cell type to cell type.
An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
UCH-L1
Product competes with ATP.
Cell permeable: no
Reversible: yes

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Liu, Y., et al. 2003. Chem. Biol.10, 837.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C17H11Cl3N2O3
分子量397.64
MDL编号MFCD09037562

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
效能0.88 μM IC50
0.40 μM Ki
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 orange
溶解性DMSO: 20 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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