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PAD Inhibitor, Cl-amidine-Calbiochem

PAD 抑制剂,Cl-脒-Calbiochem

品牌
Sigma-Aldrich
货号
506282
规格纯度
Cl-amidine is a cell-permeable pan PAD inhibitor (IC50 = 0.8, 6.2, and 5.9 μM for PAD1, PAD3, and PAD4, respectively). Inactivates the calcium bound form of PAD4 in an irreversible manner.
参考价格
3352.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. It preferentially inactivates the calcium bound form of PAD4 in an irreversible manner, and is shown to complete with BAEE for the active site residue of this enzyme. A small but significant reduction in the efficiency of p300GDB-GRIP1 interaction is observed in transiently transfected CV-1 cells treated with Cl-amidine at concentrations between 25 µM and 200 µM, in vivo. Furthermore, this compound (200 µM) together with HDAC inhibitor SAHA (0.4 µM) has shown additive effects in inducing p21, GADD45, and PUMA expression and inhibiting cancer cell growth in a p53-dependent manner in U2OS cells.

包装

10 mg in Glass bottle

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Knuckley, B., et al. 2010. Biochemistry23, 4852.
Li, P., et al. 2010. Oncogene21, 3153.
Luo, Y., et al. 2006. Biochemistry39, 11727.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C16H20ClF3N4O4
分子量424.80
NACRESNA.77

产品性质

质量水平200
测定>95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white
溶解性DMSO: 50 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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