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XIE62-1004

品牌
Sigma-Aldrich
CAS
500899-98-9
货号
SML2638
规格纯度
≥98% (HPLC)
参考价格
1467.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 μM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 μM, 18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectants, as well as in wild-type, but not autophagy defective Atg5-/- MEFs (GFP-HDQ103).

基本信息

经验(实验)分子式C23H25NO3 · HCl
分子量399.91

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性H2O: 2 mg/mL, clear
储存温度2-8℃
SMILES stringOCCNCC1=CC(OCC2=CC=CC=C2)=C(C=C1)OCC3=CC=CC=C3.Cl

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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