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WM-1119

品牌
Sigma-Aldrich
CAS
2055397-28-7
货号
SML3067
规格纯度
≥98% (HPLC)
参考价格
1053.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).

基本信息

经验(实验)分子式C18H13F2N3O3S
分子量389.38
MDL编号MFCD31690337

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringFC1=CC(C2=NC=CC=C2)=CC(C(NNS(C3=CC=CC=C3F)(=O)=O)=O)=C1

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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