位置:首页 > 品牌 > Sigma-Aldrich >

VU0463271

品牌
Sigma-Aldrich
CAS
1391737-01-1
货号
SML2333
规格纯度
≥98% (HPLC)
参考价格
744.44 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

VU0463271 is a potent and selective potassium-chloride cotransporter 2 (KCC2) inhibitor that displays greatly enhanced potency than its structural analogs VU0255011 (ML077) & VU0240511 (IC50 = 61, 537, and 568 nM, respectively). VU0463271 exhibits much reduced efficacy against the related Na-K-2Cl cotransporter 1 (NKCC1 inhibition max ~37% at 100 μM) and little affinity toward a panel of 68 GPCRs, ion channels, and transporters. Although VU0463271 is reported to exhibit affinity toward mitochondrial translocator protein TSPO (IC50 of 204 nM against PK11195 binding; rat heart) and inhibitory potency against α1B adrenergic receptor (IC50 of 364.7 nM; human α1B CHO transfectants), these proteins are not known to affect chloride homeostasis.

基本信息

经验(实验)分子式C19H18N4OS2
分子量382.50
MDL编号MFCD30182240

产品性质

测定≥98% (HPLC)
形式powder
颜色 off-white to blue-gray
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号