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SRPIN340

品牌
Sigma-Aldrich
CAS
218156-96-8
货号
SML1088
规格纯度
≥98% (HPLC)
参考价格
1168.11 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SRPIN340 has been used as a serine-arginine protein kinase (SRPK) inhibitor to identify if SRPK can phosphorylate the E3 ubiquitin ligase RNF12 ser/arg (SR)-motifs in vivo.

包装

5, 25 mg in glass bottle

生化/生理作用

SRPIN340 is a cell-permeable, specific and potent inhibitor of Serine-Arginine-Rich Protein Kinase (SRPK) that down-regulates SRp75 and inhibits expression of Sindbis, hepatitis C virus (HCV), HIV, and cytomegalovirus viruses. SRPIN340 appears to be most effective for inhibiting acutely replicating viruses. SRPIN340 suppresses Vegf expression and attenuated choroidal neovascularization (CNV) formation in mice model.
SRPIN340 is an isonicotinamide compound. It protects cardiomyocytes against hydrogen peroxide (H2O2) induced oxidative damage by serine-arginine protein kinase 1/2 (SRPK1/2) inhibition-mediated protein kinase B (AKT) activation.

基本信息

经验(实验)分子式C18H18F3N3O
分子量349.35
MDL编号MFCD00116244
PubChem化学物质编号329825465
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(C1=CC=NC=C1)NC2=C(N3CCCCC3)C=CC(C(F)(F)F)=C2
InChI1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
InChI keyDWFGGOFPIISJIT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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