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SF1670

品牌
Sigma-Aldrich
CAS
345630-40-2
货号
SML0684
包装型号
规格纯度
≥98% (HPLC)
参考价格
2862.54 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SF1670 has been used:

  • To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
  • To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
  • To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

包装

5, 25 mg in glass bottle

生化/生理作用

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.

基本信息

经验(实验)分子式C19H17NO3
分子量307.34
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色, light pink to red to very dark purple
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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