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SB 328437

品牌
Sigma-Aldrich
CAS
247580-43-4
货号
SML0207
包装型号
规格纯度
≥98% (HPLC)
参考价格
1528.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

包装

5, 25 mg in glass bottle

生化/生理作用

SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.
SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.

特点和优势

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C21H18N2O5
分子量378.38
MDL编号MFCD16618397
PubChem化学物质编号329825229
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to tan
溶解性DMSO: ≥10 mg/mL
创始人GlaxoSmithKline
储存温度2-8℃
SMILES stringCOC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
InChI1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChI keyVMFGCGRAIBLAFY-IBGZPJMESA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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