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PKUMDL-WQ-2201

品牌
Sigma-Aldrich
CAS
592474-91-4
货号
SML1965
规格纯度
≥98% (HPLC)
参考价格
1048.99 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2201 binds to allosteric site II, which is located in the substrate-binding domain. PKUMDL-WQ-2201 inhibits tumor growth of MDA-MB-468 xenografts in mice.

基本信息

经验(实验)分子式C15H14ClN3O3S
分子量351.81

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to brown
溶解性DMSO: 15 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(C(C=CC(C1=CC=C(C=NNC(NCC)=S)O1)=C2)=C2Cl)O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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