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Phenanthriplatin

品牌
Sigma-Aldrich
货号
SML2811
规格纯度
>97% (NMR)
参考价格
940.27 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Phenanthriplatin is a cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity (IC50 in μM = 0.035/Ntera2, 0.22/A549, 0.30/HeLa, 0.59/U2OS, 0.74/PC3, 0.94/MCF7, 2.02/HT29; 72 h, MTT assay) than cisplatin, oxaliplatin, and pyriplatin. Enhanced cellular uptake due to its hydrophobic phenanthridine ligand as well as more rapid DNA covalent-binding activity both contribute to its superior anticancer efficacy. Phenanthriplatin binds more effectively to 5′-deoxyguanosine monophosphate than to N-acetyl methionine, whereas pyriplatin reacts equally to both.

基本信息

经验(实验)分子式C13H15ClN4O3Pt
分子量505.81

产品性质

质量水平100
测定>97% (NMR)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringCl[Pt](N)([N+]1=C2C=CC=CC2=C3C=CC=CC3=C1)N.[O-][N+]([O-])=O

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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