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PF-06807656

品牌
Sigma-Aldrich
货号
PZ0402
规格纯度
≥98% (HPLC)
参考价格
936.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMK, CCNJ1, Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) that is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over rat species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or rat ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or rat ROMK2-expressing HEK293 cells).

法律信息

Sold for research purposes under agreement from Pfizer Inc.

基本信息

经验(实验)分子式C19H20ClN5O4S
分子量449.91

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(NC(C1=NN(C)N=C1)C)C(C=C2S(=O)(NC3=CC=C(Cl)C=C3)=O)=CC=C2OC

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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