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OG-L002 hydrochloride

4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride

品牌
Sigma-Aldrich
CAS
1357299-45-6
货号
SML1383
规格纯度
≥98% (HPLC)
参考价格
2280.72 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

OG-L002 is a recently developed inhibitor with IC50 of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 μM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition.

基本信息

经验(实验)分子式C15H15NO · HCl
分子量261.75
PubChem化学物质编号329825831
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色, light yellow to dark orange
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringN[C@@H]1[C@@H](C(C=C2)=CC=C2C3=CC=CC(O)=C3)C1.Cl
InChI1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1
InChI keyLPVCAMIPTMRRLZ-LIOBNPLQSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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