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O4I3

品牌
Sigma-Aldrich
CAS
88965-00-8
货号
SML2886
规格纯度
≥98% (HPLC)
参考价格
623.38 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

O4I3 is a highly potent and KDM5A (JARID1A) subtype-selective H3K4 demethylase KDM5 inhibitor (KDM5A IC50 = 0.15 nM vs KDM5B/C/D IC50 = 125.2/9.76/4.7 nM, KDM4 IC50 = 249 nM, LSD1 IC50 >100 μM) that effectively induces OCT4 expresson and improves OSKM-induced pluripotent stem cell (iPSC) reprogramming efficiency of human primary fibroblasts (50 nM) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter. O4I3 promotes hPSC homeostasis and represses cellular differentiation, increasing hPSCs viability up to 4-fold at a low 10 nM concentration when compared with Rock inhibitor Y-27632 treatment at 10 μM.

基本信息

经验(实验)分子式C15H14N2
分子量222.29
MDL编号MFCD00444739

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringCC1=CC=C(C2=CN3C=C(C=CC3=N2)C)C=C1

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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