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NSC43067

品牌
Sigma-Aldrich
CAS
26903-26-4
货号
N0915
包装型号
规格纯度
≥98% (HPLC)
参考价格
6372.58 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

特点和优势

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C14H12OS
分子量228.31
MDL编号MFCD00489751
PubChem化学物质编号329818472
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色light yellow to light tan
溶解性DMSO: >20 mg/mL
储存温度2-8℃
SMILES stringCc1ccc(s1)C(=O)\C=C\c2ccccc2
InChI1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+
InChI keyAOUMOFQEBZGSPD-CMDGGOBGSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H413
预防措施声明P264 - P270 - P273 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral - Aquatic Chronic 4
储存分类代码11 - Combustible Solids
闪点(F)Not applicable
闪点(C)Not applicable

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