产品介绍:
产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.
基本信息
经验(实验)分子式 | C23H19N3O · HBr |
分子量 | 434.33 |
MDL编号 | MFCD00559986 |
PubChem化学物质编号 | 329825795 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | , faint red to dark red |
溶解性 | DMSO: 10 mg/mL, clear |
储存温度 | 2-8℃ |
SMILES string | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
InChI | 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 |
InChI key | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H315 - H319 - H335 - H400 |
预防措施声明 | P273 - P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 - P391 |
危险分类 | Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
靶器官 | Respiratory system |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |