产品说明
一般描述
Nifurtimox acts as a hypoxia-activated cytotoxin, which specifically kills clonogenic tumor cells under hypoxic conditions. It is used to treat Chagas disease and African trypanosomiasis. Nifurtimox inhibits neuroblastoma and medulloblastoma cell growth.
应用
Nifurtimox has been used in drug treatment in culture media.
包装
5, 25 mg in glass bottle
生化/生理作用
Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen.
特点和优势
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
基本信息
| 经验(实验)分子式 | C10H13N3O5S |
| 分子量 | 287.29 |
| EC 号 | 245-531-0 |
| MDL编号 | MFCD00869254 |
| PubChem化学物质编号 | 329818609 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | yellow to orange |
| 溶解性 | DMSO: ≥13 mg/mL |
| 创始人 | Bayer |
| 储存温度 | room temp |
| SMILES string | CC1CS(=O)(=O)CCN1\N=C\c2ccc(o2)[N+]([O-])=O |
| InChI | 1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+ |
| InChI key | ARFHIAQFJWUCFH-IZZDOVSWSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
