产品说明
应用
NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.
包装
5, 25 mg in glass bottle
生化/生理作用
NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC50 value >57 μM for PHGDH. NCT-503 has an IC50 value of 2.5 μM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.
推荐产品
The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here.
基本信息
经验(实验)分子式 | C17H21N5S |
分子量 | 327.45 |
PubChem化学物质编号 | 329826006 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | white to beige |
溶解性 | DMSO: 5 mg/mL, clear (warmed) |
储存温度 | 2-8℃ |
SMILES string | CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1 |
InChI | 1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23) |
InChI key | ITLPIAAGIQAGRA-UHFFFAOYSA-N |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H315 |
危险分类 | Skin Irrit. 2 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |