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N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

品牌
Sigma-Aldrich
CAS
300670-16-0
货号
B3436
规格纯度
≥98% (HPLC), solid
参考价格
2266.84 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

基本信息

经验(实验)分子式C19H14Br2N2O3S
分子量510.20
MDL编号MFCD00355835
PubChem化学物质编号24724418

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 off-white
溶解性DMSO: ~20 mg/mL
H2O: insoluble
储存温度2-8℃
SMILES stringBrc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1
InChI1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)
InChI keySJJKUNDBFWUAQB-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H319 - H413
预防措施声明P273 - P305 + P351 + P338
危险分类Aquatic Chronic 4 - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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