产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.
基本信息
| 经验(实验)分子式 | C15H15NO4S |
| 分子量 | 305.35 |
| PubChem化学物质编号 | 329826041 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | powder |
| 颜色 | off-white to purple |
| 溶解性 | DMSO: 25 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1 |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
