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LY404039

品牌
Sigma-Aldrich
CAS
635318-11-5
货号
SML2269
规格纯度
≥98% (HPLC)
参考价格
733.26 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

LY404039 is a potent and selective group II metabotropic glutamate receptors mGluR2/3 agonist (Ki = 15 nM against against [3H]LY341495 for binding rat neurons; Ki = 149 nM and 92 nM, respectively, using membrane from human mGluR2- or mGluR3-expressing cells) with >100-fold selectivity over 16 other receptors/transproters, including iGluRs and EAAT1/2/3. LY404039 inhibits forskolin-stimulated c-AMP production in RGT cells expressing human mGluR2 (EC50 = 23 nM) or mGluR3 (EC50 = 48 nM) with little or no potency toward mGluR1a/5a/4a/6/7a/8a-expressing cells (EC50 >10 μM). LY404039 is orally available (Cmax 1528.5 ng/mL, Tmax 2 h; 10 mg/kg p.o. in rats) and exhibits antipsychotic and anxiolytic efficacy in rats (3-30 mg/kg) in vivo.

基本信息

经验(实验)分子式C7H9NO6S
分子量235.21
MDL编号MFCD11974011

产品性质

测定≥98% (HPLC)
形式powder
旋光性[α]/D -69 to -79°, c = 1.0 in 1 M NaOH
颜色 white to gray
溶解性DMSO: 2 mg/mL, clear (warmed)
储存温度−20℃
SMILES string[H][C@]1([C@@](C(O)=O)(N)C2)[C@@]([C@@H]1C(O)=O)([H])S2(=O)=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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