产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
JW651 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). JW651 inhibited mouse MAGL with an IC50 ~38 nM compared to 10,380 for ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG and >100,000 for FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). JW651 was used as the MAGL inhibitor along with JW912, a fluorescent inihibitor of both MAGL and ABHD6.
特点和优势
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基本信息
| 经验(实验)分子式 | C21H18Cl2F6N2O2 |
| 分子量 | 515.28 |
| MDL编号 | MFCD28137685 |
| PubChem化学物质编号 | 329825626 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 10 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | ClC1=CC=C(C(C2=CC=C(Cl)C=C2)N3CCN(C(OC(C(F)(F)F)C(F)(F)F)=O)CC3)C=C1 |
| InChI | 1S/C21H18Cl2F6N2O2/c22-15-5-1-13(2-6-15)17(14-3-7-16(23)8-4-14)30-9-11-31(12-10-30)19(32)33-18(20(24,25)26)21(27,28)29/h1-8,17-18H,9-12H2 |
| InChI key | UPIHQFKOCOKGEO-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
