产品说明
应用
JW55 has been used as a tankyrase-specific inhibitor to study its effects on the transcriptional activity of SRY-related HMG-box gene 9 (Sox9) in chondrocytes.
包装
5, 25 mg in glass bottle
生化/生理作用
JW55 is a potent and selective inhibitor of Wnt/β-catenin signaling, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) leading to stabilization of AXIN2 followed by increased degradation of β-catenin. JW55 specifically inhibits canonical Wnt signaling that results in reduced cell-cycle progression, proliferation, and colony formation in colon carcinoma cell lines.
JW55 can decrease the formation of mouse colon adenoma in vivo. It possesses a methoxyphenyl moiety spreading towards the G-loop.
其他说明
JW55 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JW55 probe summary on the Chemical Probes Portal website.
基本信息
| 经验(实验)分子式 | C25H26N2O5 |
| 分子量 | 434.48 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 15 mg/mL, clear |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
