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Ispinesib

品牌
Sigma-Aldrich
CAS
336113-53-2
货号
SML2869
规格纯度
≥98% (HPLC)
参考价格
833.87 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Ispinesib (SB-715992) is a potent and highly selective kinesin spindle protein (KSP, KIF11, EG5) allosteric inhibtor that specifically inhibits microtubule (MT)-stimulated ATPase activity of KSP (Ki = 1.7 nM; 5 μM MT, 500 μM ATP, 0.75 nM human KSP), but not ubiquitous kinesin heavy chain KHC, neuronal kinesin KIF1A, or mitotic kinesins CENP-E, RabK6, MCAK, MKLP1. Ispinesib exhibits anti-cancer efficacy in cultures (GI50 = 45 nM/BT-474 & 19 nM/MDA-MB-468) and in cancer xenograft models in vivo (8 or 10 mg/kg q4d×3 ip. mice with MCF-7, HCC-1954, KPL4, BT-474 xenografts).

基本信息

经验(实验)分子式C30H33ClN4O2
分子量517.06
MDL编号MFCD22628831

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D +315 to +375°, c = 0.5 in chloroform-d
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

象形图GHS06GHS08
警示用语:Danger
危险声明H300 + H330 - H341
预防措施声明P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
危险分类Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Muta. 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3

Sigma-Aldrich

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