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GW833972A

品牌
Sigma-Aldrich
CAS
1092502-33-4
货号
G8173
规格纯度
≥98% (HPLC), powder
参考价格
2185.87 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent.

包装

5, 25 mg in glass bottle

生化/生理作用

The compound was used to determine the role of CB2 in airway sensory nerve function.
GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.

基本信息

经验(实验)分子式C18H13ClF3N5O · HCl
分子量444.24
MDL编号MFCD18452844
PubChem化学物质编号329799976
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
drug controlregulated under CDSA - not available from sigma-aldrich Canada
储存条件desiccated
颜色 off-white to light brown
溶解性DMSO: ≥20 mg/mL
储存温度2-8℃
SMILES stringCl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3
InChI1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H
InChI keyUBHSVFAUAKIVKL-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H315 - H319 - H335 - H413
预防措施声明P273 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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