产品说明
生化/生理作用
EU1794-27 is an N-methyl-d-aspartate (NMDA) receptor (NMDAR) positive allosteric modulator (PAM) toward GluN2A/B/C subtypes (EC50/Emax = 1.4 μM/130%/GluN2B, 2.8 μM/230%/GluN2C, 2.4 μM/250%/GluN2D with Glu/Gly = ECmax = 100/30 μM using xenopus oocytes co-expressing rat GluN1 and respective GluN2 subtype; EC50/Emax = 6.3 μM/400%/GluN2B, 5.0 μM/680%/GluN2C with Glu/Gly = 1/0.3 μM &,;2.4 μM/580%/GluN2D with Glu/Gly = 0.6/0.2 μM), while it exhibits Glu/Gly level-dependent GluN1-GluN2A-modulating activities (EC50/Emax = 7.4 μM/52%/GluN2A with Glu/Gly = 100/30 μM; 8.1 μM/340% with Glu/Gly = 2/0.6 μM).
NMDA receptor is important for glutamate neurotransmission. It is associated with learning ability and memory. NMDA receptor possesses two different subunits NMDAR1 and NMDAR2. Tyrosine phosphorylation controls the actions of NMDA receptors. It is also known to influence neuronal function.
基本信息
| 经验(实验)分子式 | C18H23N3O4S2 |
| 分子量 | 409.52 |
产品性质
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to light brown |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(C(CC(NC1=C(C(OC(C)(C)C)=O)C2=C(CCCC2)S1)=O)S3)NC3=N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
