C14 Ceramide (d18:1/14:0)

产品介绍：

产品说明

一般描述

Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids. The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi. Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramide.

应用

C14 Ceramide (d18:1/14:0) is suitable for use

as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS²) for ceramide quantification from muscel biopsies
in lipid monolayer preparation for biophysical studies
in the morphological and dimensional evaluation studies

生化/生理作用

Ceramides regulate biological processes including proliferation, differentiation and apoptosis. In the cystic fibrosis patients, elevated levels of C14 ceramide is observed. It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio. Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.

包装

5 mL Amber Glass Screw Cap Vial (860514P-25mg)
5 mL Amber Glass Screw Cap Vial (860514P-5mg)

基本信息

经验(实验)分子式	C₃₂H₆₃NO₃
分子量	509.85
NACRES	NA.25

产品性质

形式	powder
包装	pkg of 1 × 25 mg (860514P-25mg) pkg of 1 × 5 mg (860514P-5mg)
manufacturer/tradename	Avanti Polar Lipids 860514P
运输	dry ice
储存温度	−20℃
SMILES string	OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

安全信息

储存分类代码

13 - Non Combustible Solids