产品说明
应用
Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.
包装
5, 25 mg in glass bottle
生化/生理作用
Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.
Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.
注意
Extremely hygroscopic.
基本信息
| 经验(实验)分子式 | C8H16ClNO2 · HCl |
| 分子量 | 230.13 |
| MDL编号 | MFCD00055153 |
| PubChem化学物质编号 | 329774756 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | >97% (GC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white |
| mp | 78-81 ℃ |
| 溶解性 | H2O: >5 mg/mL ethanol: soluble methanol: soluble |
| 储存温度 | −20℃ |
| SMILES string | Cl[H].CCN(CCCl)CCOC(C)=O |
| InChI | 1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H |
| InChI key | CHWPASAPXMNLKO-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H300 + H310 + H330 - H315 - H319 - H335 - H370 |
| 预防措施声明 | P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3 |
| 靶器官 | Nervous system, Respiratory system |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | 204.8 °F - closed cup |
| 闪点(C) | 96 ℃ - closed cup |
