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ABT-418 hydrochloride

ABT-418 盐酸盐

品牌
Sigma-Aldrich
CAS
147388-83-8
货号
A6476
规格纯度
powder, ≥98% (HPLC)
参考价格
2741.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

ABT-418 is an α4β2 agonist of nicotinic receptors.

应用

ABT-418 hydrochloride has been used as a nicotinic acetylcholine receptor (nAChR) agonist to test its effect on spatial memory improvement in attention deficit hyperactivity disorder (ADHD) rat model
ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer′s disease.

包装

5, 25 mg in glass bottle

生化/生理作用

Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.

特点和优势

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.

基本信息

经验(实验)分子式C9H14N2O · HCl
分子量202.68
MDL编号MFCD11045960
PubChem化学物质编号24724395
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
溶解性H2O: soluble 15 mg/mL
创始人Abbott
SMILES stringCl.CN1CCC[C@H]1c2cc(C)no2
InChI1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
InChI keyVOXHERKWAIEJQF-QRPNPIFTSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H300 + H310 + H330
预防措施声明P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
危险分类Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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