产品说明
一般描述
Valdecoxib (VCX) is a diaryl substituted isoxazole compound. It comprises of sulfonyl propanamide and is a metabolite of parecoxib.
应用
Valdecoxib may be used: as cyclooxygenase-2 (COX-2) inhibitor in fibroblast cells, as an analyte for mass spectrometry analysis, as an standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for quantification of valdecoxib in plasma samples
包装
5, 25 mg in glass bottle
生化/生理作用
Valdecoxib is reported to elicit anti-inflammatory, analgesic and antipyretic functionality. It acts as a substrate for the liver enzyme cytochrome P450 2C9(CYP2C9) and cytochrome P450 3A4 (CYP3A4).
Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) selective inhibitor.
其他说明
This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
基本信息
| 经验(实验)分子式 | C16H14N2O3S |
| 分子量 | 314.36 |
| MDL编号 | MFCD00950568 |
| PubChem化学物质编号 | 329823753 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Pfizer® |
| 颜色 | white to off-white |
| 溶解性 | DMSO: >25 mg/mL |
| 创始人 | Pfizer |
| 储存温度 | room temp |
| SMILES string | Cc1onc(-c2ccccc2)c1-c3ccc(cc3)S(N)(=O)=O |
| InChI | 1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) |
| InChI key | LNPDTQAFDNKSHK-UHFFFAOYSA-N |
| Gene Information | human ... PTGS2(5743) |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H361d - H373 - H410 |
| 预防措施声明 | P201 - P202 - P260 - P273 - P280 - P308 + P313 |
| 危险分类 | Aquatic Chronic 1 - Repr. 2 - STOT RE 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
